This lecture is intended to give a flavor of the value of Particle Physics: can we use the state-of-the-art technologies, tools and techniques developed for fundamental physics experiments in the field of High Energy Physics (HEP) to others applications of interest to society? High energy and particle physics has considerable acquired knowledge, expertise and resources that can, when transferred in a realistic way, significantly impact other fields of applications like the practice of medical imaging for diagnostic and therapy, safeguarding homeland security, environmental sciences and severe nuclear accident monitoring. This overview introductory talk of 90 minutes “from basic science to the human reality” intends to show how successful technology transfer between fundamental research in Particle Physics and other fields of applications can be achieved using specific examples. Using as input the recent advance of HEP state-of-the-art techniques and tools in detectors developments like solid-state and gaseous detectors, calorimeters, photodetectors, fast signal processing,read-out electronics, trigger, data acquisition and simulations, this talk will provide examples of some direct applications in medical and molecular imaging like Positron Emission Tomography (PET), Computed Tomography (CT), Particle Therapy (pCT),X-Ray imaging and many others.